Women's views and postpartum follow-up in the CHIPS Trial (Control of Hypertension in Pregnancy Study)

The CHIPS Study Group

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Abstract

Objective To compare women's views about blood pressure (BP) control in CHIPS (Control of Hypertension In Pregnancy Study) (NCT01192412). Design Quantitative and qualitative analysis of questionnaire responses. Setting International randomised trial (94 sites, 15 countries). Population/sample 911 (92.9%) women randomised to ‘tight’ (target diastolic blood pressure, 85 mmHg) or ‘less tight’ (target diastolic blood pressure, 100 mmHg) who completed questionnaires. Methods A questionnaire was administered at ∼6–12 weeks postpartum regarding post-discharge morbidity and views about trial participation. Questionnaires were administered by the site co-ordinator, and contact was made by phone, home or clinic visit; rarely, data was collected from medical records. Quantitative analyses were Chi-square or Fisher's exact test for categorical variables, mixed effects multinomial logistic regression to adjust for confounders, and p < 0.001 for statistical significance. NVivo software was used for thematic analysis of women's views. Main outcome measures Satisfaction, measured as willingness to have the same treatment in another pregnancy or recommend that treatment to a friend. Results Among the 533 women in ‘tight’ (N = 265) vs. ‘less tight’ (N = 268) control who provided comments for qualitative analysis, women in ‘tight’ (vs. ‘less tight’) control made fewer positive comments about the amount of medication taken (5 vs. 28 women, respectively) and intensity of BP monitoring (7 vs. 17, respectively). However, this did not translate into less willingness to either have the same treatment in another pregnancy (434, 95.8% vs. 423, 92.4%, respectively; p = 0.14) or recommend that treatment to a friend (435, 96.0% and 428, 93.4%, respectively; p = 0.17). Importantly, although satisfaction remained high among women with an adverse outcome, those in ‘tight’ control who suffered an adverse outcome (vs. those who did not) were not consistently less satisfied, whereas this was not the case among women in ‘less tight’ control among whom satisfaction was consistently lower for the CHIPS primary outcome (p < 0.001), severe hypertension (p ≤ 0.01), and pre-eclampsia (p < 0.001). Conclusions Women in ‘tight’ (vs. ‘less tight’) control were equally satisfied with their care, and more so in the face of adverse perinatal or maternal outcomes.
Original languageEnglish
Pages (from-to)105-113
Number of pages9
JournalEuropean Journal of Obstetrics Gynecology and Reproductive Biology
Volume206
DOIs
Publication statusPublished - 2016

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