Zinc protoporphyrin/heme ratio as parameter of iron status in moderately preterm infants: Natural course and associations in the first 4 months

C. G. De Waal, L. Uijterschout, M. Abbink, B. Boersma, P. Vos, W. W. Rövekamp, F. Hudig, M. D. Akkermans, J. B. Van Goudoever, F. Brus

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective:To determine the natural course of zinc protoporphyrin/heme ratio (ZnPP/H) and its role in the detection of iron deficiency (ID) and iron-deficiency anemia (IDA) in the first 4 months of life in moderately preterm infants.Study Design:ZnPP/H was measured at 1 week, 6 weeks and 4 months postnatal age in a prospective cohort of 161 Dutch infants born at a gestational age of 32+0 to 36+6 weeks who did not receive an erythrocyte transfusion or iron supplementation.Results:ZnPP/H levels decreased in the first 6 weeks and increased thereafter. At 4 months postnatal age, ZnPP/H was higher in the 11 (8.5%) infants with IDA (mean (s.d.): 260.8 (16.1)) but not in the 27 (21.3%) infants with ID (mean (s.d.): 177.0 (15.1)) compared with normal infants (mean (s.d.): 157.3 (12.5)).Conclusion:In moderately preterm infants, ZnPP/H can be of additional value to detect infants at risk for IDA due to iron-deficient erythropoiesis at 4 months of age.

Original languageEnglish
Pages (from-to)690-694
Number of pages5
JournalJournal of Perinatology
Volume37
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

Cite this

De Waal, C. G. ; Uijterschout, L. ; Abbink, M. ; Boersma, B. ; Vos, P. ; Rövekamp, W. W. ; Hudig, F. ; Akkermans, M. D. ; Van Goudoever, J. B. ; Brus, F. / Zinc protoporphyrin/heme ratio as parameter of iron status in moderately preterm infants : Natural course and associations in the first 4 months. In: Journal of Perinatology. 2017 ; Vol. 37, No. 6. pp. 690-694.
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abstract = "Objective:To determine the natural course of zinc protoporphyrin/heme ratio (ZnPP/H) and its role in the detection of iron deficiency (ID) and iron-deficiency anemia (IDA) in the first 4 months of life in moderately preterm infants.Study Design:ZnPP/H was measured at 1 week, 6 weeks and 4 months postnatal age in a prospective cohort of 161 Dutch infants born at a gestational age of 32+0 to 36+6 weeks who did not receive an erythrocyte transfusion or iron supplementation.Results:ZnPP/H levels decreased in the first 6 weeks and increased thereafter. At 4 months postnatal age, ZnPP/H was higher in the 11 (8.5{\%}) infants with IDA (mean (s.d.): 260.8 (16.1)) but not in the 27 (21.3{\%}) infants with ID (mean (s.d.): 177.0 (15.1)) compared with normal infants (mean (s.d.): 157.3 (12.5)).Conclusion:In moderately preterm infants, ZnPP/H can be of additional value to detect infants at risk for IDA due to iron-deficient erythropoiesis at 4 months of age.",
author = "{De Waal}, {C. G.} and L. Uijterschout and M. Abbink and B. Boersma and P. Vos and R{\"o}vekamp, {W. W.} and F. Hudig and Akkermans, {M. D.} and {Van Goudoever}, {J. B.} and F. Brus",
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Zinc protoporphyrin/heme ratio as parameter of iron status in moderately preterm infants : Natural course and associations in the first 4 months. / De Waal, C. G.; Uijterschout, L.; Abbink, M.; Boersma, B.; Vos, P.; Rövekamp, W. W.; Hudig, F.; Akkermans, M. D.; Van Goudoever, J. B.; Brus, F.

In: Journal of Perinatology, Vol. 37, No. 6, 01.06.2017, p. 690-694.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Zinc protoporphyrin/heme ratio as parameter of iron status in moderately preterm infants

T2 - Natural course and associations in the first 4 months

AU - De Waal, C. G.

AU - Uijterschout, L.

AU - Abbink, M.

AU - Boersma, B.

AU - Vos, P.

AU - Rövekamp, W. W.

AU - Hudig, F.

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AU - Van Goudoever, J. B.

AU - Brus, F.

PY - 2017/6/1

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N2 - Objective:To determine the natural course of zinc protoporphyrin/heme ratio (ZnPP/H) and its role in the detection of iron deficiency (ID) and iron-deficiency anemia (IDA) in the first 4 months of life in moderately preterm infants.Study Design:ZnPP/H was measured at 1 week, 6 weeks and 4 months postnatal age in a prospective cohort of 161 Dutch infants born at a gestational age of 32+0 to 36+6 weeks who did not receive an erythrocyte transfusion or iron supplementation.Results:ZnPP/H levels decreased in the first 6 weeks and increased thereafter. At 4 months postnatal age, ZnPP/H was higher in the 11 (8.5%) infants with IDA (mean (s.d.): 260.8 (16.1)) but not in the 27 (21.3%) infants with ID (mean (s.d.): 177.0 (15.1)) compared with normal infants (mean (s.d.): 157.3 (12.5)).Conclusion:In moderately preterm infants, ZnPP/H can be of additional value to detect infants at risk for IDA due to iron-deficient erythropoiesis at 4 months of age.

AB - Objective:To determine the natural course of zinc protoporphyrin/heme ratio (ZnPP/H) and its role in the detection of iron deficiency (ID) and iron-deficiency anemia (IDA) in the first 4 months of life in moderately preterm infants.Study Design:ZnPP/H was measured at 1 week, 6 weeks and 4 months postnatal age in a prospective cohort of 161 Dutch infants born at a gestational age of 32+0 to 36+6 weeks who did not receive an erythrocyte transfusion or iron supplementation.Results:ZnPP/H levels decreased in the first 6 weeks and increased thereafter. At 4 months postnatal age, ZnPP/H was higher in the 11 (8.5%) infants with IDA (mean (s.d.): 260.8 (16.1)) but not in the 27 (21.3%) infants with ID (mean (s.d.): 177.0 (15.1)) compared with normal infants (mean (s.d.): 157.3 (12.5)).Conclusion:In moderately preterm infants, ZnPP/H can be of additional value to detect infants at risk for IDA due to iron-deficient erythropoiesis at 4 months of age.

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